Surgical management of intracranial subependymomas
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Julia Annabel Kandenwein , Azize Bostroem , Mareike Feuss , Torsten Pietsch , Matthias Simon
- چاپ و سال / کشور: 2011
Description
Background Intracranial subependymomas are rare, slowgrowing and usually non-invasive tumors. The aim of this study was to analyze our experience with the surgical treatment of intracranial subependymomas. Methods Between 1991 and 2007, 11 patients with intracranial subependymomas had surgery in our institution. Mean age of the patients was 54.4 years (ranging from 40 to 85 years). Results Tumors were located in the fourth ventricle in seven patients and in the lateral ventricle in four patients. Most patients presented with symptoms related to intracranial hypertension and/or cerebellar signs and symptoms (headache: eight patients; dizziness: six patients; nausea: six patients; gait ataxia: four patients), one patient with cognitive decline and flattened affect, and one patient with a hemiparesis. Six patients presented with hydrocephalus, but only one needed a permanent cerebrospinal fluid (CSF) shunt. Complete removal of the tumor was possible in eight cases. Following surgery, only one patient experienced a permanent drop of his Karnofsky Performance Index (from 70 to 60). Median follow-up was 37 months. There were no true recurrences during follow-up. A second surgery was required 7 years after the first operation for progression of an incompletely resected tumor. Conclusions Removal of symptomatic subependymomas can be performed safely. Prognosis is excellent after a complete resection. The potential for a surgical cure, low surgical complication rates and the risk of undertreatment of a more aggressive tumor together may justify surgery for asymptomatic lesions
Acta Neurochir (2011) 153:1469–1475 DOI 10.1007/s00701-011-1007-4 Received: 30 January 2011 / Accepted: 24 March 2011 / Published online: 16 April 2011 # Springer-Verlag 2011
