Surgical treatment of choroid plexus tumors
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Azize Bostrِm , Jan P. Bostrِm , Marec von Lehe , Julia A. Kandenwein , Johannes Schramm , Matthias Simon
- چاپ و سال / کشور: 2011
Description
Purpose The purpose of this study is to evaluate the results of microsurgical treatment for choroid plexus tumors (CPT) in adult patients. Methods From 1990 to 2008, 14 patients >18 years were treated at our institution for CPT, including seven males and seven females with a mean age of 46 years. Mean follow-up was 40 months. We reviewed the respective patients' charts, operative, and follow-up notes. Telephone interviews were performed as necessary. Neurological status was determined using the Karnofsky performance index pre- and post-operatively and at last follow-up. Results This series includes 12 plexus papillomas (CPP) and two atypical plexus papillomas (APP). Ten tumors were located in the fourth ventricle, two tumors in the cerebellopontine angle, one growth each in the third and lateral ventricle. In 12 cases, a complete tumor resection was achieved. No recurrence was observed in these cases. Two recurrent CPP were diagnosed 11 and 25 years after the initial surgery. Brain stem infiltration prevented a complete tumor removal in one case. In the other, the degree of resection after the first operation could not be ascertained. None of the patients received adjuvant chemo- or radiotherapy. In four patients (29%), a permanent ventricularperitoneal shunt was necessary. Three patients initially presented with a Karnofsky index of 60 or below. During follow-up, three patients (21%) never improved beyond a Karnofsky index of 60. Conclusions Surgery aiming radical excision is the key to successful treatment of CPP and APP in adults. Postoperative outcomes may be less than satisfactory in some patients.
Acta Neurochir (2011) 153:371–376 DOI 10.1007/s00701-010-0828-x Received: 11 June 2010 / Accepted: 28 September 2010 / Published online: 9 October 2010 # Springer-Verlag 2010
