Surgical site infection associated with the use of bovine serum albumine-glutaraldehyde surgical adhesive (BioGlue®) in cranial surgery: a case–control study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Thomas Gaberel , France Borgey & Pascal Thibon , Claire Lesteven , Xavier Lecoutour , Evelyne Emery
- چاپ و سال / کشور: 2011
Description
Purpose To enhance the water tightness of dura mater closure in cranial surgery, an organic glue called BioGlue® was used in our neurosurgical department between January 2006 and June 2007. During this period of time, we noticed an important increase in the surgical site infection (SSI) incidence. We conducted a case– control study to identify risk factors for these infections. Our objective was to test the hypothesis that BioGlue® was one of the risk factors. Methods Cases with infection were defined retrospectively. We included two controls per case. Study data were age, sex, time of year, in stay hospital preoperative time, length of surgery, type of surgery, surgeon, use of BioGlue®, and use of duraplasty. We first performed a univariate analysis and then the significant variables were introduced in a logistic regression model. Results Thirty patients were defined as cases (60 controls). In multivariate analysis, risk factors were young age (p= 0.04), extended operative length (p=0.02) and the use of BioGlue (p=0.007). The combined use of BioGlue® and Neuropatch® appeared to be a significant risk factor for SSI (p=0.002). Conclusions BioGlue® seems to increase the risk of SSI for patients who underwent craniotomy, especially when associated with synthetic dural graft. BioGlue® triggers an intense inflammatory response, which causes wound breaches allowing bacteria to spread down in the wound, and then creates an ideal environment for bacterial growth.
Acta Neurochir (2011) 153:156–163 DOI 10.1007/s00701-010-0830-3 Received: 17 July 2010 / Accepted: 28 September 2010 / Published online: 7 October 2010 # Springer-Verlag 2010
