Natural history of spheno-orbital meningiomas
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Peerooz Saeed , Wouter R. van Furth , Michael Tanck , Fabio Kooremans , Nicole Freling , Geert I. Streekstra , Noortje I. Regensburg , Jan Willem B
- چاپ و سال / کشور: 2011
Description
Background To investigate the natural history and the growth rate of spheno-orbital meningiomas (SOMs). Methods Ninety patients with a diagnosis of SOM were included, and patient charts and imaging were evaluated. In a subset of 32 patients, volumetric studies were performed. Results The median follow-up for the entire group was 4 years (range, 1–15); the mean age was 47.8 (range, 26–93) years; 94% of the patients were female. The most common clinical signs and symptoms were proptosis (93%), visual deterioration (65%), retro-bulbar pain (23%) and diplopia (6%). In 35% of patients in this series, no visual deterioration occurred, and in 30% only mild proptosis was present. The median annual growth rate of the SOMs in the subset of 32 patients was 0.3 cm3/year (range, 0.03–1.8 cm3/year). We assessed a trend for more rapid tumour growth in younger patients and found the initial volume of the tumour (rho=0.63) and of the soft tissue component (rho=074) to be significantly related to the growth rate. Conclusion SOMs are slow-growing tumours that cause primarily proptosis and visual deterioration. In a significant number of patients, these tumours cause minimal discomfort and symptomatology. Therefore, in the absence of risk factors, we advocate a “wait and see” policy. For patients with large SOMs or with a large soft tissue component at first visit or with fast growing SOMs (>1cm3/year), a follow-up examination every 6 months is indicated.
Acta Neurochir (2011) 153:395–402 DOI 10.1007/s00701-010-0878-0 Received: 24 June 2010 / Accepted: 8 November 2010 / Published online: 1 December 2010 # The Author(s) 2010. This article is published with open access at Springerlink.com
