A pilot study: differential effects of methylphenidate-OROS on working memory and attention functions in children with attention-deficit/hyperactivity disorder with and without behavioural comorbidities
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Bele´n Rubio Sergio Herna´ndez Emilio Verche Raquel Mart´n Pedro Gonza´lez-Pe´rez
- چاپ و سال / کشور: 2010
Description
To examine the effects of methylphenidate- OROS (MPH-OROS) on working memory (WM) and attention functions in children with attention-deficit hyperactivity disorder (ADHD), and to investigate whether there is a differential effect in ADHD children with (ADHD?) and without (ADHD-) behavioural comorbidities. Participants included a clinic referred sample of 12 stimulant na¨ve school-aged children with a diagnosis of combined ADHD according to the DSM-IV criteria (6 ADHD?, 6 ADHD-), and 11 healthy children. A neuropsychological protocol was applied at three different moments: before treatment, after one those of MPH-OROS, and after one month of MPH-OROS daily treatment. The protocol was simultaneously administered to the control group. Initial differences in attention parameters between na¨ve children with ADHD and the control group disappeared after the first dose of MPH-OROS. For WM, one month of daily treatment was necessary to achieve this pattern of results. Both ADHD groups (ADHD? and ADHD-) showed these differences, but there was a greater improvement in (ADHD-). MPH-OROS had an immediate effect on attention deficits, but long-term treatment was needed to improve WM to the level of healthy subjects. The presence of comorbid behavioural conditions determined a less robust response in neuropsychological performance to stimulant treatment.
ADHD Atten Def Hyp Disord (2011) 3:13–20 DOI 10.1007/s12402-010-0035-x Received: 8 July 2010 / Accepted: 1 October 2010 / Published online: 21 October 2010
