Reduced intensity allogeneic hematopoietic cell transplantation can induce durable remission in heavily pretreated relapsed Hodgkin lymphoma
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Robert Chen & Joycelynne M. Palmer & Leslie Popplewell & Jessica Shen & Eileen Smith & Maria Delioukina & Neil Kogut & Joseph Rosenthal & Stephen For
- چاپ و سال / کشور: 2011
Description
Hodgkin lymphoma (HL) can be aggressive and intractable in some cases. Patients who relapse after autologous HCT (auto-HCT) have limited treatment options. City of Hope reports our experience in the use of reduced intensity allogeneic hematopoietic cell transplantation (allo-HCT) in 24 heavily pretreated patients with relapsed HL, between January 2003 and December 2008. The median number of prior therapies was 5; 20/24 patients had prior auto-HCT. The conditioning regimen for all patients was fludarabine and melphalan. With a median follow-up for living patients of 39.0 months, at 2 years the overall survival (OS) was 60% (95% CI 42, 72) and the progression-free survival was 27% (95% CI 22, 32). Nonrelapse mortality was 13.1% (95% CI 5.1, 31.4) at 2 years. The incidence of grade II–IV aGVHD was 45.8% and 8.3% for grade III–IV. Allo-HCT in heavily pretreated relapsed Hodgkin lymphoma is feasible, tolerable, and can induce durable clinical remissions.
Ann Hematol (2011) 90:803–808 DOI 10.1007/s00277-010-1146-3 Received: 3 November 2010 / Accepted: 20 December 2010 / Published online: 6 January 2011
