Differential expression of JAK2 and Src kinase genes in response to hydroxyurea treatment in polycythemia vera and essential thrombocythemia
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Enriqueta Albizua & Miguel Gallardo & Santiago Barrio & Inmaculada Rapado & Ana Jimenez & Rosa Ayala & Daniel Rueda & Beatriz Sanchez-Espiridion & E
- چاپ و سال / کشور: 2011
Description
This study investigates the differential gene expression profile of JAK2V617F-positive myeloproliferative neoplasm (MPN) patients, with and without response to hydroxyurea (HU) treatment. Twenty-one polycythemia vera, 28 essential thrombocythemia, eight secondary erythrocytosis, and 30 controls were studied. Thirty-four genes were overexpressed in patients who did not respond to HU. Of these, some participate in proliferative pathways: MAPK, AKT, Src kinase (SFK), and JAK2 pathway. JAK2 allele burden was similar between groups of responders and nonresponder. A molecular fingerprint distinguishes JAK2V617F-positive MPN patients without response to HU treatment, with overexpression of JAK2, MAPK14, PIK3CA, and SFK genes
Ann Hematol (2011) 90:939–946 DOI 10.1007/s00277-011-1179-2 Received: 10 December 2010 / Accepted: 31 January 2011 / Published online: 18 February 2011
