Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Eric Tse & Anskar Y. H. Leung & Joycelyn Sim & Harold K. K. Lee & Herman S. Y. Liu & Sze-Fai Yip & Yok-Lam Kwong
- چاپ و سال / کشور: 2011
Description
Clofarabine (40 mg/m2/day×5) and high-dose cytosine arabinoside (Ara-C, 1–2 g/m2/day×5) were used in 10 men and 11 women, at a median age of 45 (22–62) years, with refractory (N=4) and relapsed (N=17) acute myeloid leukaemia, after a median of 3 (2–5) prior regimens. Grade 4 myelosuppression was observed in all cases, with two patients dying of bacterial sepsis. Nine patients achieved a complete remission. Disease status, number of prior therapies, and cytogenetic aberrations were not associated with the outcome. However, remission was only achieved with Ara-C at 2 g/m2/day and not 1 g/m2/day (9/15 versus 0/4, P=0.03).
Ann Hematol DOI 10.1007/s00277-011-1223-2 Received: 5 March 2011 / Accepted: 21 March 2011
