Determination of the survival rate in patients with congestive heart failure stratified by 123I-MIBG imaging: a meta-analysis from the studies performed in Japan
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yoichi Kuwabara Nagara Tamaki Tomoaki Nakata Shohei Yamashina Junichi Yamazaki
- چاپ و سال / کشور: 2011
Description
Background The goals of this meta-analysis were to determine survival rates in patients with heart failure (HF) assessed by 123I-MIBG imaging results using recently published studies and to determine the prognostic value of 123I-MIBG imaging. Methods We reviewed published cohort studies carried out in Japan that compared the prognosis of patients with their 123I-MIBG activity quantified as late heart-to-mediastinum ratio (H/M) or washout rate by performing a PubMed search for articles in English up to December 2006. Studies were selected if they analyzed a clearly defined lethal outcome (cardiovascular death) using life tables to estimate the odds ratio at 24 months after enrollment. Results Of 158 articles related to cardiac 123I-MIBG, seven referred to studies that met the inclusion criteria: 5 evaluated H/M via 123I-MIBG in a total of 866 patients and 4 calculated washout rate in a total of 491 patients. A low H/M indicated a high risk of cardiac death: pooled odds ratio, 5.2; 95% confidence interval (CI) of 3.1–5.7. A high washout was also associated with lethal events with a pooled odds ratio of 2.8 (CI: 1.6–5.0). The association between washout and cardiac death was heterogeneous (Chi-square = 11.0, P\0.02), whereas that between late H/M and fatal events was homogeneous (Chi-square = 2.3, P = no significance). Conclusion This meta-analysis of published studies of 123I-MIBG studies conducted in Japan indicated that both a decreased cardiac 123I-MIBG activity (H/M) and an increased washout rate are indicative of a poor prognosis in patients with chronic heart failure.
Ann Nucl Med (2011) 25:101–107 DOI 10.1007/s12149-010-0452-0 Received: 30 April 2010 / Accepted: 17 September 2010 / Published online: 6 January 2011
