18F-FDG uptake in primary lung cancer as a predictor of intratumoral vessel invasion
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Tetsuya Ishibashi Mitsuhito Kaji Tatsuya Kato Keidai Ishikawa Masatoshi Kadoya Nagara Tamaki
- چاپ و سال / کشور: 2011
Description
Objective This study investigated how fluorodeoxyglucose (FDG) uptake on PET in the primary tumor may predict intratumoral vessel invasion (IVI) in it. Methods A total of 512 patients with lung neoplasms determined by a surgical procedure and histopathological diagnosis had undergone FDG-PET scanning. Results Among the 440 cases confirmed to be malignant, the maximum standardized uptake value (SUVmax) was significantly lower in IVI-negative cases than IVI-positive cases (P\0.001). In the substudy on adenocarcinoma (AC), SUVmax was significantly lower in IVI-negative cases too (P\0.001), but SUVmax in squamous cell carcinoma was without significant difference. In addition, IVI was associated with a significantly higher probability of lymph node metastasis (P\0.001). Conclusions This study indicates that a malignant lung tumor with higher SUVmax has a significantly higher probability of IVI and lymph node metastasis, particularly if the malignancy is an AC.
Ann Nucl Med DOI 10.1007/s12149-011-0502-2 Received: 1 February 2011 / Accepted: 2 May 2011
