Loss of heterozygosity analysis in malignant gliomas
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Masahiro Mizoguchi Daisuke Kuga Yanlei Guan Nobuhiro Hata Akira Nakamizo Koji Yoshimoto Tomio Sasaki
- چاپ و سال / کشور: 2011
Description
Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy. Some of the identified molecular markers—such as loss of heterozygosity (LOH) on chromosome 1p/19q and chromosome 10, O6-methylguanine methyltransferase promoter hypermethylation, and mutation of isocitrate dehydrogenase-1—may help to predict patient outcomes. Indeed, LOH analysis is an effective approach to classify malignant gliomas. Genomewide analyses have revealed that the extent and pattern of LOH regions may have important implications for the clinical course of the disease. As the genetic underpinnings of malignant gliomas are complex and varied, careful selection of the methods for genetic analysis in the clinic is important. The fundamental principles of each assay need to be understood to allow careful selection of practically useful methods. This review summarizes recent developments in the molecular analysis of malignant glioma.
Brain Tumor Pathol (2011) 28:191–196 DOI 10.1007/s10014-011-0038-0Received: 31 March 2011 / Accepted: 1 May 2011 / Published online: 1 June 2011 The Japan Society of Brain Tumor Pathology 2011
