New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ichiyo Shibahara Yukihiko Sonoda Masayuki Kanamori Ryuta Saito Toshihiro Kumabe Teiji Tominaga
- چاپ و سال / کشور: 2011
Description
In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.
Brain Tumor Pathol (2011) 28:203–208 DOI 10.1007/s10014-011-0050-4 Received: 18 May 2011 / Accepted: 14 June 2011 / Published online: 7 July 2011 The Japan Society of Brain Tumor Pathology 2011
