A case of atypical teratoid/rhabdoid tumor in an adult, with long survival
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kenta Takahashi Hiroshi Nishihara Masahito Katoh Tomoaki Yoshinaga Roshan Mahabir Hiromi Kanno Taichi Kimura Mishie Tanino Jun Ikeda
- چاپ و سال / کشور: 2011
Description
Atypical teratoid/rhabdoid tumor (AT/RT) is a malignant tumor that mostly occurs in early childhood and has poor prognosis despite aggressive therapy. Adult cases are rare and, as far as we are aware, only 30 cases have been reported to date. Here we present the case of a 27-year-old female with left parietal AT/RT with the chief complaint of numbness of the right superior limb. First, the tumor was surgically removed and the diagnosis was grade II glioma. With additional radiotherapy, the clinical course after surgery was favorable. After 6 years, she had an operation for recurrence and the diagnosis was grade III glioma. Temozolomide was prescribed, and a disease-free period of 2 years followed. Surgery was performed for a third time for second recurrence with histology of diffuse growth of rhabdoid cells. Immunohistochemistry was partially positive for vimentin and epithelial membrane antigen. Ki-67 labeling index was extremely high and tumor cells showed no staining of INI1 suggestive of diagnosis of AT/RT. We reevaluated past specimens and none had immunoreactivity of INI1. Ki-67 labeling index and O-6 methylguanine DNA methyltransferase (MGMT) staining were also re-examined and both increased gradually. She is still alive without recurrence for more than 1 year. As far as we are aware, this is the second longest survival of an adult with AT/RT
Brain Tumor Pathol (2011) 28:71–76 DOI 10.1007/s10014-010-0008-y Received: 6 September 2010 / Accepted: 5 October 2010 / Published online: 23 December 2010 The Japan Society of Brain Tumor Pathology 2010
