A case of multinodular high-grade neuroepithelial tumor with ependymal differentiation
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kensaku Kamada Yuko Tanaka Takayuki Matsuo Shiro Baba Kenta Ujifuku Kazuhiko Suyama Yoichi Nakazato Izumi Nagata
- چاپ و سال / کشور: 2011
Description
We describe a rare case of multinodular cerebral neuroepithelial tumor with ependymal differentiation. A 65-year-old man experienced loss of consciousness with an obscure episode of seizure attack. Magnetic resonance images disclosed a lesion located in the left temporal lobe and the insular cortex. The tumor was partially removed. Histologically, the tumor showed infiltrating multinodular tumor nodules in the cerebrum. Each nodule was well demarcated and composed of clear cells with perinuclear halos, intermingled fibrillary cells, and poorly differentiated neuroepithelial cells with mitotic activity. Immunohistochemically, clear cells showed dot-like positivity for epithelial membrane antigen. Fibrillary cells were positive for vimentin and nestin, whereas only a few glial fibrillary acidic protein-immunopositive cells were seen. We conclude that this tumor, being microscopically characterized by multinodular tumor nodules, was a high-grade neuroepithelial tumor with ependymal differentiation.
Brain Tumor Pathol (2011) 28:253–257 DOI 10.1007/s10014-011-0032-6 Received: 4 November 2010 / Accepted: 5 March 2011 / Published online: 8 April 2011 The Japan Society of Brain Tumor Pathology 2011
