Genomics, histopathology, and the tumor microenvironment: new relationship or old friends re-discovered?
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Daniel W. Visscher
- چاپ و سال / کشور: 2010
Description
Efforts to improve recurrence risk stratification for breast cancer patients have increasingly focused on rapidly developing gene expression profiling and informatics technologies. Already, these powerful innovations have advanced and ‘‘personalized’’ evaluation of tumors to a degree not seen since application of histopathology. Genomic assays have also stimulated new and valuable insights into classical pathological features. For example, many of the genes that comprise well-studied expression profiles or prognostic assays, such as intrinsic subtype or OncotypeDXTM, either mediate, control, or measure tumor cell proliferation. It is therefore no surprise that these profiles are highly correlated with pathologic tumor grade, particularly mitotic index.
Breast Cancer Res Treat (2011) 125:697–698 DOI 10.1007/s10549-010-0930-z Received: 17 April 2010 / Accepted: 28 April 2010 / Published online: 15 May 2010 Springer Science+Business Media, LLC. 2010
