A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Furu Wang Zhibin Hu Rongxi Yang Jinhai Tang Yao Liu Kari Hemminki Christian Sutter Barbara Wappenschmidt Dieter Niederacher arbara B
- چاپ و سال / کشور: 2010
Description
Disruption of the circadian rhythm has been reported to increase the risk of breast cancer. A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we found a novel functional SNP (rs3739008) located at 30UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 30UTR of NPAS2. We then typed this SNP in case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer risk. However, we failed to find any significant associations by different genetic models (dominant genetic model, adjusted OR = 1.13, 95% CI = 0.95–1.35 for the Chinese population and adjusted OR = 0.99, 95% CI = 0.85–1.16 for the Germany population). Although we did not find significant associations at population levels from both Chinese and Germany case–control studies, due to the functional relevance of rs3739008 on NASP2 expression, it will be promising to investigate the influence of this variant on clinical characteristics of breast cancer and breast cancer survival.
Breast Cancer Res Treat (2011) 127:769–775 DOI 10.1007/s10549-010-1157-8 Received: 12 February 2010 / Accepted: 27 August 2010 / Published online: 8 December 2010 Springer Science+Business Media, LLC. 2010
