Associations between mammographic density and serum and dietary cholesterol
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ame-Lia Tamburrini Christy G. Woolcott Norman F. Boyd Martin J. Yaffe Tim Terry Yutaka Yasui Charlotte A. Jones Scott B. Patten Kerry
- چاپ و سال / کشور: 2010
Description
Although high mammographic density is a risk factor for postmenopausal breast cancer, its etiology remains unclear. We examined whether serum and dietary cholesterol, which increase breast cancer risk and are involved in endogenous estrogen formation, were associated with increased mammographic density. We conducted a cross-sectional analysis of 302 healthy, sedentary postmenopausal women, aged 50–74 years, enrolled in the Alberta Physical Activity and Breast Cancer Prevention Trial between 2003 and 2006. In multiple linear regression models, no significant associations were observed between serum lipids and percent density or dense tissue area (Percent density: b (change in square root percent density per unit change in cholesterol level) = -0.06 (95%CI = -0.26 to 0.13); b = 0.06 (95%CI = -0.48 to 0.61); and b = -0.11 (95%CI = -0.33 to 0.10) for total cholesterol, high-, and low-density lipoprotein, respectively; similar results found for dense area). Alcohol consumption modified the association between triglycerides and percent density ([1 drink/day: b = -0.94 (95%CI = -1.79 to -0.10); B1 drink/day: b = 0.19 (95%CI = -0.12 to 0.50); and no alcohol consumption: b = 0.15 (95%CI = -0.44 to 0.73). We found no evidence indicating any association between dietary and serum cholesterol levels and mammographic density.
Breast Cancer Res Treat (2011) 125:181–189 DOI 10.1007/s10549-010-0927-7 Received: 24 November 2009 / Accepted: 28 April 2010 / Published online: 13 May 2010 Springer Science+Business Media, LLC. 2010
