Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Rinat Yerushalmi Karen A. Gelmon Samuel Leung Dongxia Gao Maggie Cheang Michael Pollak Gulisa Turashvili Blakes C. Gilks Hagen Kennec
- چاپ و سال / کشور: 2011
Description
Insulin-like growth factor-1 receptor (IGF-1R) is expressed in normal and malignant breast tissue and has been implicated in cell survival and resistance to cytotoxic therapies. We sought to assess the prognostic impact of IGF-1R expression among patients with early breast cancer and among breast cancer subtypes. Patients with stages I–III breast cancer with archival tumor tissue were included. Paraffin tissue blocks were used to construct a tissue microarray that was stained for ER, PR, Ki-67, HER2, EGFR, and cytokeratins 5/6 to classify the breast subgroups and for expression of IGF-1R, p27, and Bcl2 by immunohistochemistry. Kaplan–Meier plots were created by subtypes. Associations between IGF-1R and prognostic variables were examined in multivariate analysis. Among 2,871 eligible women the prognostic cut point for IGF-1R expression for breast-cancer-specific survival (BCSS) was Allred score \7 versus C7. IGF-1R was C7 in 52% (LuminalA), 57.5% (LuminalB), 44.8% (LuminalHER2), 9.7% HER2-enriched, and 22.5% (Basal-like), P = 1.3 9 10-52. IGF-1R? was associated with age C50, lower histopathology grade, ER?, HER2 negativity (-), high p27 and high Bcl2 score. IGF-1R C7 was associated with better BCSS among LuminalB patients, hazard ratio = 0.64 (0.49–0.84); P = 1.2 9 10-3, and worse outcome in the HER2-enriched subtype, hazard ratio = 2.37 (1.21–4.64); P = 0.012. IGF-1R correlates with good prognostic markers among patients with early breast cancer and is differentially expressed with variable prognostic impact among breast cancer subtypes. Results may have relevance to the development of therapeutics targeting IGF-1R.
Breast Cancer Res Treat DOI 10.1007/s10549-011-1529-8 Received: 11 August 2010 / Accepted: 16 April 2011
