Lack of association between hOGG1 Ser326Cys polymorphism and breast cancer susceptibility in European population
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Da-Peng Ding Ying Zhang Xiao-Feng He
- چاپ و سال / کشور: 2011
Description
Recently, we read with great interest the article ‘‘The hOGG1 Ser326Cys polymorphism and breast cancer risk: a meta-analysis’’ published online in August 2010 issue of ‘‘Breast Cancer Research and Treatment’’ [1]. The study of Yuan et al. performed a meta-analysis to make an estimation of the association between the DNA repair gene hOGG1 Ser326Cys polymorphism (rs1052133) and breast cancer susceptibility, and the results showed that individuals who carrying the hOGG1 326Cys allele did not have significantly increased risk of breast cancer compared with those carrying the 326Ser allele. However, in the stratified analysis by ethnicity, the meta-analysis showed the association between hOGG1 326Cys allele in the additive model, and breast cancer was significant in European subject (OR = 0.71, 95% CI = 0.51–0.98), and dominant genetic model (OR = 0.44, 95%CI = 0.25–0.77), and the 326Cys allele plays a protective effect on the carcinogenesis of breast cancer among them.
Breast Cancer Res Treat DOI 10.1007/s10549-011-1571-6 Received: 30 April 2011 / Accepted: 4 May 2011
