LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Justin Stebbing Aleksandra Filipovic Ian O. Ellis Andrew R. Green Tanya Rapoz D’Silva Heinz-Josef Lenz R. Charles Coombes Tingting Wang
- چاپ و سال / کشور: 2011
Description
Interactions between kinases and the estrogen receptor a (ERa) are thought to be a critical signaling pathway in the majority of human breast cancers. We have recently identified a previously uncharacterized molecule, lemur tyrosine kinase-3 (LMTK3) as a prognostic and predictive oncogenic ERa regulator with a central role in endocrine resistance. Unusually this protein has undergone Darwinian positive selection between Chimpanzees and humans suggesting it may contribute to human susceptibility to ERa-positive tumors. Using over 600 European primary breast cancer cases, we wished to establish tumor characteristics associated with both cytoplasmic and nuclear LMTK3 expression, and then externally validate our observed European clinical outcomes with samples from Asian individuals receiving chemotherapy. Both nuclear and cytoplasmic expression correlated with tumor grade (P\0.001) and in the Asian cohort, independent blinded analyses demonstrated that high basal LMTK3 expression was associated with advanced stage of primary breast cancers as well as decreased overall (P = 0.03) and disease-free survival (P = 0.006). In summary, higher LMTK3 expression is associated with more aggressive cancers. These data support our previous findings and suggest LMTK3 expression may be a reliable new biomarker in breast cancer.
DOI 10.1007/s10549-011-1622-z Received: 9 May 2011 / Accepted: 30 May 2011
