Radiofrequency ablation as local therapy for early breast carcinomas
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Takayuki Kinoshita Eriko Iwamoto Hitoshi Tsuda Kunihiko Seki
- چاپ و سال / کشور: 2011
Description
Purpose To evaluate the safety and efficacy of radiofrequency ablation (RFA) as a local therapy for early breast carcinomas, we performed a phase I/II study at our institution. Patients and methods Fifty patients with core-needle biopsy-proven breast carcinoma that was B3 cm in diameter on ultrasonography were enrolled in this study. Under ultrasound (US) guidance, the tumor and surrounding breast tissue were ablated with a saline-cooled RF electrode followed by immediate surgical resection. Resected specimens were examined by hematoxylin and eosin (H&E) staining and nicotinamide adenine dinucleotide (NADH) diaphorase staining to assess tumor viability. Results Forty-nine patients completed the treatment. The mean tumor size was 1.70 cm. The mean ablation time was 8.7 min using a mean power of 48.5 W. Of the 49 treated patients, complete ablation was recognized in 30 patients (61%) by H&E staining and/or NADH diaphorase staining. The NADH viability staining was available for 38 patients, and in 29 (76.3%), there was no evidence of viable malignant cells. Of the 29 treated patients with breast carcinomas B2 cm in diameter examined by pathological examination, complete ablation was achieved in 24 patients (83%). Of the 26 treated patients with breast carcinomas without an extended intraductal component (EIC) according to pathological examination, complete ablation was determined in 22 patients (85%). RFA-related adverse events were observed in five cases: two with skin burn and three with muscle burns. Conclusion RF ablation is a safe and promising minimally invasive treatment for small breast carcinomas with pathological tumor size B2 cm in diameter and without EIC
Breast Cancer (2011) 18:10–17 DOI 10.1007/s12282-009-0186-9 Received: 21 July 2009 / Accepted: 26 October 2009 / Published online: 14 January 2010 The Japanese Breast Cancer Society 2010
