MR and US imaging for breast cancer patients who underwent conservation surgery after neoadjuvant chemotherapy: comparison of triple negative breast cancer and other intrinsic subtypes
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Hiroshi Nakahara Yukiko Yasuda Eiichiro Machida Yorio Maeda Hidemi Furusawa Kansei Komaki Mayumi Funagayama Mayumi Nakahara Shozo Tamu
- چاپ و سال / کشور: 2011
Description
Background Neoadjuvant chemotherapy (NAC) is commonly utilized to treat operable breast cancer. The purpose of this study was to review the findings of ultrasonography (US) and magnetic resonance (MR) imaging in patients treated with breast conservation surgery (BCS) after NAC with a focus on intrinsic subtypes. Methods Eighty-six patients underwent BCS after NAC. The tumors were classified into four subgroups by receptor status. US and MR were performed before and after NAC. The tumor diameters in US and MR after NAC were examined for correlations with pathological tumor distances in the specimens from BCS after NAC. Results The correlation coefficient (r) of US to pathological tumor size was 0.3 in all tumors, 0.6 in HER2-type tumors, and 0.7 in triple negative breast cancers (TNBC). The correlation coefficient of tumor size in MR to pathological tumor size was 0.9 in TNBC, and other correlations were not statistically significant. Conclusions The correlation between tumor size in MR and pathological tumor size in triple negative breast cancers corresponded best. This information is one of the clues to selecting patients for BCS after NAC.
Breast Cancer (2011) 18:152–160 DOI 10.1007/s12282-010-0235-4 Received: 15 July 2010 / Accepted: 23 September 2010 / Published online: 18 November 2010 The Japanese Breast Cancer Society 2010
