Immunohistochemical expression of epidermal growth factor receptor in breast cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Tadahiro Nozoe Emiko Mori Tomohiro Iguchi Akinori Egashira Eisuke Adachi Akito Matsukuma Takahiro Ezaki
- چاپ و سال / کشور: 2011
Description
cancer expressing epidermal growth factor receptor (EGFR) would be clinically valuable. The aim of the current study was to determine the further significance of immunohistochemical expression of EGFR in breast cancer. Methods The immunohistochemical expression of EGFR was examined in 37 women with breast cancer who had been treated with surgical resection. Relationship of EGFR expression and clinicopathological characteristics was investigated. Results EGFR expression proved to be comparatively more frequent among triple-negative (estrogen receptor negative, progesterone receptor negative, and human epidermal growth factor receptor 2 negative) breast cancers (P = 0.067). Conclusions Knowledge of a patient’s immunohistochemical EGFR expression, which could be one of the key molecular findings related to molecular-targeting therapy, might be useful information to treat triple-negative breast cancer.
Breast Cancer (2011) 18:37–41 DOI 10.1007/s12282-010-0200-2 Received: 26 October 2009 / Accepted: 27 January 2010 / Published online: 4 March 2010 The Japanese Breast Cancer Society 2010
