Detection of circulating tumor cells in peripheral blood of heavily treated metastatic breast cancer patients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Nahomi Tokudome Yoshinori Ito Shunji Takahashi Kokoro Kobayashi Shinichiro Taira Chizuko Tsutsumi Masafumi Oto Masaru Oba Kenichi Inou
- چاپ و سال / کشور: 2011
Description
Background Circulating tumor cells (CTCs) are detected in peripheral blood of breast cancer patients, and they may play an important role as a prognostic and predictive marker. We conducted this study to determine the presence of CTCs with the CellSearch SystemTM and the clinical significance in treatment of metastatic breast cancer (MBC). Method Twenty-eight MBC patients were enrolled. These patients were followed by assessing CTCs, imaging studies, and serum tumor markers. Blood samples were collected before starting a new treatment and at the treatment evaluation period (2–3 months after starting chemotherapy). The cutoff for CTC level was 5. Results At baseline, 9 of 28 patients (32%) had C5 CTCs per 7.5 mL of blood. At the evaluation period, 5 of 23 patients (22%) had C5 CTCs. The baseline CTC number did not contribute to determine their overall survival (OS); however, CTCs at the evaluation period were available to predict their OS (p\0.001). In two cases, both CTCs and tumor markers were available as predictors of treatment efficacy. In two other cases, although alterations of tumor markers might not reflect disease condition, CTC alteration corresponded to their condition. One patient who had multiple skeletal metastasis only, experienced a decrease in her CTCs in spite of tumor marker alteration. Conclusions We suggest that monitoring the number of CTCs may be helpful in predicting the efficacy of the treatment and the prognosis. CTCs might be especially useful with patients whose lesions are difficult to assess
Breast Cancer (2011) 18:195–202 DOI 10.1007/s12282-011-0259-4 Received: 25 October 2010 / Accepted: 17 February 2011 / Published online: 5 April 2011 The Japanese Breast Cancer Society 2011
