Serum appearance of anti-p53 antibody in triple negative breast cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Tadahiro Nozoe Emiko Mori Mayuko Kono Tomohiro Iguchi Takashi Maeda Akito Matsukuma Takahiro Ezaki
- چاپ و سال / کشور: 2010
Description
Background Significance of serum appearance of anti-p53 antibody in breast cancer has not been discussed fully. Methods The relationship between serum appearance of anti-p53 antibody and the clinicopathological features was investigated on the basis of the data of 42 women with breast cancer who had been treated with surgical resection. Results The proportion of tumors with histological grade 3 was significantly higher among tumors with serum appearance of anti-p53 antibody (P = 0.020). The proportion of triple negative tumors was also significantly higher among tumors with serum appearance of anti-p53 antibody (P = 0.003). Conclusions Preoperative appearance of anti-p53 antibody in sera can be correlated with the incidence of triple negative breast cancer and could therefore help identify tumors with aggressive potential
Breast Cancer DOI 10.1007/s12282-010-0244-3 Received: 15 June 2010 / Accepted: 7 October 2010 The Japanese Breast Cancer Society 2010
