Anastrozole can cause severe hypercalcaemia mimicking primary hyperparathyroidism
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Johannes Ja¨rhult
- چاپ و سال / کشور: 2010
Description
65-year-old woman on anastrozole treatment because of a recurrent breast cancer developed hypercalcaemia and increased parathyroid hormone (PTH) levels 2 years after start of the treatment. A diagnosis of hyperparathyroidism was suspected and the patient underwent neck surgery, but only normal parathyroid glands were found. Postoperatively, the hypercalcaemia as well as the PTH level continued to rise, and 9 months after exploration of the parathyroids her calcium level was extremely high (adjusted serum calcium = 3.39 mmol/l). Anastrozole was then withheld, and within 2 weeks the severe hypercalcaemic state turned into hypocalcaemia. A month later, anastrozole treatment was started again, and after 6 weeks her calcium and PTH values had returned to extremely high levels. After withdrawal of anastrozole, calcium and PTH concentrations again fell toward normal values. The urinary excretion of calcium was very low during anastrozole treatment and high after cessation of the drug. The mechanism(s) by which anastrozole can cause hypercalcaemia are unknown. However, it might be hypothesised that anastrozole, directly or indirectly, interferes with the calcium-sensing receptors known to be present on the cell surface of both parathyroid and renal tubular cells.
Breast Cancer DOI 10.1007/s12282-011-0253-x Received: 28 October 2010 / Accepted: 28 December 2010 The Japanese Breast Cancer Society 2011
