Comparison of the Anti-tumor Effects of Two Platinum Agents (Miriplatin and Fine-Powder Cisplatin)
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Shobu Watanabe Norihisa Nitta Shinichi Ohta Akinaga Sonoda Hideji Otani Yuki Tomozawa Ayumi Nitta-Seko Keiko Tsuchiya Toyohiko Tanka
- چاپ و سال / کشور: 2011
Description
Purpose This study was designed to evaluate the antitumor effects of miriplatin-lipidol and fine-powder cisplatin– lipiodol suspensions. Methods Assessment of the cytotoxicity of two drugs was performed: a soluble derivative of miriplatin (DPC) and fine-powder cisplatin. We randomly divided 15 rabbits with transplanted VX2 liver tumors into three equal groups. They were infused via the proper hepatic artery with a miriplatin-lipiodol suspension (ML), a fine-powder cisplatin- lipiodol suspension (CL), or saline (control) and the tumor growth rate was determined on MR images acquired before and 7 days after treatment. The concentration of platinum (PCs) in blood was assayed immediately, and 10, 30, and 60 min, and 24 h and 7 days after drug administration. Its concentration in tumor and surrounding normal liver tissues was determined at 7 days postadministration. Results At high concentrations, fine-powder cisplatin exhibited stronger cytotoxicity than DPC. At low concentrations, both agents manifested weak cytotoxicity. While there was no difference between the tumor growth rate of the ML and the CL groups, the difference between the controls and ML- and CL-treated rabbits was significant. The blood PCs peaked at 10 min and then gradually decreased over time. On the other hand, no platinum was detected at any point after the administration of ML. There was no difference between the ML and CL groups in the PCs in tumor tissues; however, in normal hepatic tissue, the PCs were higher in ML- than CL-treated rabbits. Conclusions Weconfirmed the anti-tumor effect ofMLand CL. There was no significant difference between the antitumor effect of ML and CL at 7 days postadministration.
Cardiovasc Intervent Radiol DOI 10.1007/s00270-011-0172-4 Received: 4 February 2011 / Accepted: 18 April 2011
