Synergistic effects of apelin and leptin on isolated rat pulmonary arteries
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Irina L. Dumitriu1*, Luminita G. Vata1, Florin E. Zugun1,2, Bogdan Gurzu1
- چاپ و سال / کشور: 2011
Description
Apelin (AP) and leptin (LEP) are adipokines with vasomotor actions. Taking into account the published data on the role of obesity in the development of pulmonary hypertension, we studied the implications of apelin on leptin relaxing effects on isolated rat pulmonary arteries. LEP had vasodilatatory effects on phenylephrine-precontracted rat pulmonary arteries from normal and ovalbumin-sensitized rats, but not on rats with monocrotaline-induced pulmonary hypertension. AP13 pretreatment increased LEP effects by one-half. Our studies revealed the existence of synergistic favorable effects of these adipokines on pulmonary vessels.
Cent. Eur. J. Med. , 6(4) , 2011 , 490-496 DOI: 10.2478/s11536-011-0033-1 Received 13 August 2010; Accepted 31 March 2011
