Observed magnetic resonance imaging changes in pediatric patients treated with stereotactic radiosurgery for intracranial tumors
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Sameer K. Nath & Ruben Carmona & Brent S. Rose & Daniel R. Simpson & Michelle Russell & Joshua D. Lawson & Arno J. Mundt & Kevin T. Murphy
- چاپ و سال / کشور: 2010
Description
Purpose This study seeks to characterize magnetic resonance imaging (MRI) changes following stereotactic radiosurgery (SRS) of pediatric brain malignancies. Methods Serial MRI evaluations were performed on 21 lesions treated with SRS for either medulloblastoma (n=12), juvenile pilocytic astrocytoma (n=4), ependymoma (n=2), atypical rhabdoid teratoid tumor (n=2), or pineocytoma (n=1). Prescription doses ranged from 14 to 30 Gy in one to five fractions. Tumor response was qualified as complete (CR), partial (PR), stable disease (SD), or progressive disease (PD) according to the RECIST v1.1. Median radiographic follow-up after SRS was 17 months. Results A total of 80 follow-up MRI scans were reviewed with a median of eight per patient. During serial MRI evaluation, eight lesions met criteria for PD at a median of 6 months. However, of these, three (37%) represented transient tumor edema with two lesions later developing a CR at a median of 15 months and one persisting as SD at 12 months. The remaining five lesions were true local failures. Of the 13 lesions that did not show evidence of PD, a CR was obtained in 11 lesions at a median of 3 months (range, 2–6), and SD was seen in the remaining two tumors at last follow-up. Conclusion Lesion enlargement following SRS for pediatric intracranial tumors is common, and a proportion of patients meeting requirements for PD at early radiographic follow-up may later develop complete resolution of their lesions. Physicians should be aware of these radiographic changes to avoid unwarranted medical and surgical interventions.
Childs Nerv Syst (2011) 27:399–406 DOI 10.1007/s00381-010-1288-6 Received: 10 July 2010 / Accepted: 30 July 2010 / Published online: 7 October 2010
