High-dose chemotherapy followed by autologous and allogeneic peripheral blood stem cell transplantation for recurrent disseminated trilateral retinoblastoma
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Toshihisa Tsuruta & Yasuo Aihara & Hitoshi Kanno & Chikako Kiyotani & Katsuya Maebayashi & Masako Sakauchi &Makiko Osawa & Hisaichi Fujii & Osami Kubo
- چاپ و سال / کشور: 2011
Description
Introduction Trilateral retinoblastoma (TRb) is an intracranial neurogenic tumor associated with unilateral or bilateral retinoblastoma and has very poor prognosis. Patients typically die from leptomeningeal tumor dissemination. Case report A 3-year-old girl who had been diagnosed with TRb had a disseminated relapse after a tumorectomy, cerebrospinal irradiation, and conventional chemotherapy. The disseminated tumor disappeared after the first autologous peripheral blood stem cell transplantation (PBSCT) with high-dose melphalan and thiotepa. During the second complete remission, a second autologous PBSCT with high-dose busulfan and melphalan was performed. Seven months after the first PBSCT, the second relapse occurred, and we subsequently performed an allogeneic PBSCT with myeloablative chemotherapy consisting of melphalan, thiotepa, and cyclophosphamide. The patient showed clinical improvement after the allogeneic PBSCT. Conclusion Although high-dose chemotherapies have a curative effect for some patients with TRb, the prognoses of disseminated tumors are still poor. Further examination of the high-dose chemotherapy is necessary for the time, the conditioning drugs, and the hematopoietic stem cell sources.
Childs Nerv Syst (2011) 27:1019–1024 DOI 10.1007/s00381-011-1419-8 Received: 18 January 2011 / Accepted: 15 February 2011 / Published online: 19 March 2011
