Severe intra- and periventricular hemorrhage: role of arteriolosclerosis related to maternal smoke
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Luigi Matturri , Donatella Mecchia , Anna M. Lavezzi
- چاپ و سال / کشور: 2011
Description
Objective The authors aimed to describe the atherosclerotic lesions of the cerebral arterioles as a substrate of their rupture and bleeding. Methods The study was performed on the brain of nine Caucasian fetal victims of intra- and periventricular hemorrhage, all grade IV, and nine control cases. Results In the nine victims of hemorrhage, the arteriolar wall structure was altered, focally transformed into a deposit of amorphous eosinophilic material. Such changes often affected the full thickness of the wall causing rupture and hemorrhage. In eight of these cases and in two victims of the control group, the mothers were heavy cigarette smokers (15–20 cigarettes/day) before and during pregnancy. Conclusion The authors conclude that intra- and periventricular hemorrhage can be ascribed to the toxic effects of prenatal absorption of nicotine.
Childs Nerv Syst DOI 10.1007/s00381-011-1511-0 Received: 10 March 2011 / Accepted: 13 June 2011
