MRI findings in children with tuberculous meningitis: a comparison of HIV-infected and non-infected patients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Gerrit Dekker , Savvas Andronikou , Ronald van Toorn , Shaun Scheepers , Andrew Brandt ,Christelle Ackermann
- چاپ و سال / کشور: 2011
Description
Background Radiological studies on HIV infection in tuberculous meningitis (TBM) in children are limited to small, retrospective studies using CT features. They report that HIV-infected children are less likely to display meningovascular enhancement, tuberculoma formation and obstructive hydrocephalus. No similar MRI-based studies were found in the literature. Purpose The purpose of this study is to compare the MRI features of TBM in HIV-infected and uninfected children. Methods Retrospective descriptive study comparing clinical, laboratory and MRI features of 8 HIV-infected and 19 HIVuninfected children with TBM. Results Intense basal meningeal enhancement occurred less frequently (p=0.31) in HIV-infected children whilst cerebral atrophy was more commonly encountered (p=0.06) Neither finding was however of statistical significance. All HIVinfected children had visible meningeal nodules on MR imaging compared to 72% in HIV-uninfected children with TBM. No differences were noted regarding number or location of infarcts and presence of hydrocephalus. Hydrocephalus in HIV-infected children was exclusively of communicating nature. Conclusions The MRI criteria for diagnosis of TBM apply to HIV-infected children. The presence of nodular meningeal disease in all HIVinfected children has not previously been reported and requires further investigation.
Childs Nerv Syst DOI 10.1007/s00381-011-1451-8 Received: 4 April 2011 / Accepted: 4 April 2011
