Pathogenetic and therapeutic approaches to IgA nephropathy using a spontaneous animal model, the ddY mouse
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yasuhiko Tomino
- چاپ و سال / کشور: 2011
Description
IgA nephropathy is the most common primary chronic glomerulonephritis in the world and was first described by Berger et al. (J Urol Nephrol 74:694– 695;1968). Histopathologically, IgA nephropathy is characterized by expansion of the glomerular mesangial matrix with mesangial cell proliferation. Glomeruli typically contain generalized diffuse granular mesangial deposits of IgA (mainly IgA1), IgG and C3. In advanced patients, global glomerular sclerosis, crescent formation and tubulointerstitial fibrosis are marked in light microscopy. IgA nephropathy is generally considered to be an immunecomplex mediated glomerulonephritis. Although more than 40 years have passed since this disease was firstly described, the pathogenesis/initiation factors of IgA nephropathy are still obscure. The objective of this review is to explain the pathogenesis and treatment based on our previous data of ddY mouse, a spontaneous animal model for IgA nephropathy.
Clin Exp Nephrol (2011) 15:1–7 Received: 26 July 2010 / Accepted: 28 September 2010 / Published online: 6 November 2010 Japanese Society of Nephrology 2010
