Involvement of bone-marrow-derived cells in kidney fibrosis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Takashi Wada Norihiko Sakai Yoshio Sakai Kouji Matsushima Shuichi Kaneko Kengo Furuichi
- چاپ و سال / کشور: 2011
Description
Cellular mechanisms have been proposed in the pathogenesis of fibrotic processes in the kidney. In this setting, cell sources underlying the generation of matrixproducing cells in diseased kidneys have been categorized as activated resident stromal cells (e.g., fibroblasts, pericytes), infiltrating bone-marrow-derived cells (e.g., fibrocytes, T cells, macrophages), and cells derived from epithelial–mesenchymal transition/endothelial–mesenchymal transition. Among these cell sources, accumulating evidence has shed light on the involvement of bone-marrow- derived cells, including monocytes/macrophages, and a circulating mesenchymal progenitor cell, fibrocyte, in the progression of fibrosis in kidney. Bone-marrow-derived cells positive for CD45 or CD34, and type 1 (pro)collagen dependent on the chemokine and renin–angiotensin systems migrate into diseased kidneys and enhance synthesis matrix protein, cytokines/chemokines, and profibrotic growth factors, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating kidney fibrosis.
Clin Exp Nephrol (2011) 15:8–13 Received: 30 August 2010 / Accepted: 18 October 2010 / Published online: 10 December 2010 Japanese Society of Nephrology 2010
