Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kiyonari Kato Tomoki Kosugi Waichi Sato Hanayo Arata-Kawai Takenori Ozaki Naotake Tsuboi Isao Ito Hideo Tawada Yukio Yuzawa Seiichi
- چاپ و سال / کشور: 2011
Description
Background Growth factor Midkine (MK), which expresses on endothelial cells and renal proximal tubules, has been implicated in inflammation-related kidney diseases such as ischemic reperfusion-induced tubulointerstitial injury and diabetic nephropathy. The biological actions of MK are elicited through its chemotactic activity and chemokine-driven inflammatory pathway. Post-infectious glomerulonephritis is caused by the deposition of immune complexes into glomeruli by infiltrating a number of inflammatory cells. Therefore, we investigated whether MK might be involved in the pathogenesis of acute glomerulonephritis. Methods We induced endocapillary proliferative glomerulonephritis in 129/SV mice using intraperitoneal injections of a large amount of protein. Results In contrast to mice deficient in MK (Mdk-/-), Mdk?/? mice induced by protein overload demonstrated more diffuse cellular proliferation in the mesangial areas and capillary lumens, eventually leading to glomerular damage and tubulointerstitial injury. This pathological observation could be attributable to neutrophil infiltration through the chemotaxis and stimulation of the MK-macrophage inflammatory protein (MIP)-2 pathway, but appeared to be due to the MK-related immunoglobulin (Ig)G deposition and C3 activation. These findings are often seen in infectious-related glomerular injury. Furthermore, the profile of MK expression was strongly consistent with that of glomerular damage and tubulointersititial injury. Conclusion This study might provide a new insight into understanding the deleterious role of MK in endocapillary proliferative glomerulonephritis induced by protein overload.
Clin Exp Nephrol (2011) 15:346–354 Received: 5 August 2010 / Accepted: 6 January 2011 / Published online: 1 March 2011 Japanese Society of Nephrology 2011
