Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Akira Ishikawa Hiroo Kawarazaki Katsuyuki Ando Megumi Fujita Toshiro Fujita Yukio Homma
- چاپ و سال / کشور: 2011
Description
Background The aim of this study was to evaluate the renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (CoQ10). Methods Three-week-old heminephrectomized male Sprague–Dawley rats were divided into three groups (10 animals each): diet with normal (0.3%) salt, high (8%) salt, and high salt plus 600 mg/kg body weight/day of ubiquinol, for 4 weeks. Systolic blood pressure (SBP), urinary albumin (u-alb), superoxide anion generation (lucigenin chemiluminescence) and ubiquinol levels in renal tissues were examined. Results Salt loading increased SBP (111.0 ± 3.6 vs. 169.4 ± 14.3 mmHg, p\0.01) and u-alb (43.8 ± 28.0 vs. 2528.7 ± 1379.0 lg/day, p\0.02). These changes were associated with stimulation of superoxide generation in the kidney (866.3 ± 102.8 vs. 2721.4 ± 973.3 RLU/g kidney, p\0.01). However, ubiquinol decreased SBP (143.9 ± 29.0 mmHg, p\0.05), u-alb (256.1 ± 122.1 lg/day, p\0.02), and renal superoxide production (877.8 ± 195.6 RLU/g kidney, p\0.01), associated with an increase in renal ubiquinol levels. Conclusion Ubiquinol, the reduced form of CoQ10, effectively ameliorates renal function, probably due to its antioxidant effect. Thus, ubiquinol may be a candidate for the treatment of patients with kidney disease.
Clin Exp Nephrol (2011) 15:30–33 Received: 21 June 2010 / Accepted: 29 August 2010 / Published online: 28 September 2010 Japanese Society of Nephrology 2010
