The effects of raloxifene on bone turnover markers and bone mineral density in women on maintenance hemodialysis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Osamu Saito Takako Saito Shinji Asakura Taro Sugase Chiharu Ito Yasuhiro Ando Shigeaki Muto Eiji Kusano
- چاپ و سال / کشور: 2011
Description
Background Bone disease is caused not only by increased bone turnover accompanying secondary hyperparathyroidism but also by factors such as bone metabolic disorder accompanying kidney disease and postmenopausal or agerelated osteoporosis in hemodialysis patients. In this study, we investigated the effects of raloxifene on bone turnover markers and bone mineral density (BMD) in female hemodialysis patients to determine involvement of estrogen deficiency in bone disease. Methods The subjects were 47 female patients on maintenance hemodialysis. Raloxifene hydrochloride (60 mg) was administered to 21 patients for 1 year, and these patients were compared with a control group of 26 patients. Serum levels of N-terminal cross-linking telopeptide of type I collagen (NTx), bone alkaline phosphatase, and intact parathyroid hormone were measured, and BMD was determined by quantitative heel ultrasound as the speed of sound (SOS) in the calcaneus over this period. Results NTx decreased after treatment with raloxifene for 1 year, but significantly increased in the control group. SOS increased after treatment with raloxifene for 1 year, but significantly decreased in the control group. Treatment with raloxifene resulted in a significant decrease of NTx and a significant increase of SOS in subgroups of patients aged\60 and C60 years. Conclusions Treatment with raloxifene can suppress a rise in NTx and increase bone mineral density in patients around the time of menopause and in postmenopausal patients of advanced age. A reduction in bone mineral density caused by estrogen deficiency may be involved in the development of bone disease in female hemodialysis patients.
Clin Exp Nephrol (2011) 15:126–131, Received: 14 April 2010 / Accepted: 12 October 2010 / Published online: 11 November 2010 Japanese Society of Nephrology 2010
