A case of primary biliary cirrhosis that complicated with combined hepatocellular and cholangiocellular carcinoma
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Masakazu Kobayashi Kiyoshi Furuta Hiroshi Kitamura Kazuhiro Oguchi Masayuki Arai Shoichiro Koike Koh Nakazawa
- چاپ و سال / کشور: 2011
Description
Primary biliary cirrhosis (PBC) is frequently complicated with hepatocellular carcinoma (HCC), but complication with combined hepatocellular and cholangiocellular carcinoma (cHCC-CC) or cholangiocellular carcinoma (CCC) has not been reported. Here, we describe a case of PBC in which cHCC-CC occurred. The patient was a 70-year-old man who had developed jaundice at 62 years old. He was diagnosed with PBC based on a liver biopsy and blood tests. In August 2006, blood tests showed elevated alpha-fetoprotein, and a liver tumor in the right lobe and a metastatic lymphadenopathy in the back near to the head of the pancreas were detected by abdominal contrast-enhanced CT. A 18F-fluorodeoxyglucose-PET scan showed accumulation of the tracer in the tumor and in a lymph node at the back of the pancreas. The tumor and lymph node were removed, and the tumor was diagnosed pathologically as cHCC-CC based on the presence of features of HCC and CCC. This case is the first to show that a patient with PBC can develop cHCC-CC. This is of interest, since cHCC-CC may originate in hepatic stem cells or hepatic precursor cells. This case also suggests that cHCCCC should be included as a differential diagnosis for a liver tumor complicated with PBC
Clin J Gastroenterol (2011) 4:236–241. Received: 25 December 2010 / Accepted: 31 March 2011 / Published online: 19 May 2011 Springer 2011
