Imaging of focal nodular hyperplastic-like nodules in alcoholic liver cirrhosis patients using gadolinium-ethoxybenzyldiethylenetriamine pentaacetic acid magnetic resonance imaging
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Hisamitsu Miyaaki Tatsuki Ichikawa Naota Taura Satoshi Miuma Makiko Kawaguchi Ryota Kohno Hajime Isomoto Fuminao Takeshima Osamu Nakas
- چاپ و سال / کشور: 2011
Description
We report on two patients with a history of alcohol abuse who presented with multiple hepatic nodules. Dynamic computed tomography revealed multiple nodular lesions, which were enhanced at the early contrast phase and washed out at the portal phase. In the hepatobiliary phase using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging (Gd-EOBDTPA MRI), these tumors did not show any uptake, thus suggesting the presence of hepatocellular carcinoma. An ultrasound-guided biopsy revealed a slight increase in cell density, sinusoidal dilatation, and contained unpaired small arteries. According to immunohistochemical analyses, these arteries were positive for CD34 and alpha-smooth muscle actin. From these findings, the nodules were diagnosed to be focal nodular hyperplastic (FNH)-like nodules arising in alcoholic-cirrhosed livers. The differential diagnosis of FNH-like nodules arising in alcoholic liver cirrhosis and hepatocellular carcinoma is difficult with Gd-EOB-DTPA MRI, and therefore histological confirmation is necessary.
Clin J Gastroenterol (2011) 4:266–272 Received: 6 July 2010 / Accepted: 14 June 2011 / Published online: 14 July 2011 Springer 2011
