MTDH Expression in Invasive Micropapillary Carcinoma of the Breast
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jin-yan HAO Yi-ling YANG Fang-fang LIU Shuai LI Wei-dong LI Xiao-long QIAN Estifanos Paulos Li FU
- چاپ و سال / کشور: 2011
Description
Metadherin (MTDH), also known as astrocyte elevated gene-1 (AEG- 1), is a new oncogene found in recent years. Published studies have suggested that MTDH expression is up-regulated in several kinds of tumors, such as breast cancer, prostate cancer, non-small cell lung cancer, squamous cell carcinoma and renal cell carcinoma et al.[1–5] and the level of the MTDH expression is associated with tumor invasion and metastasis. Importantly, MTDH enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition[6]. Invasive micropapillary carcinoma (IMPC) is a rare and histological special type of breast cancer with high prevalence of lymphovascular invasion, high incidence of lymph node metastases and poor prognosis[7–10]. In the resent study, Li et al.[11] found that the increased proportion of CD44+/CD242/low tumor cells and the epithelialmesenchymal transition may play an important role in tumor invasion and metastasis of breast IMPC.
Clin Oncol Cancer Res (2011) 8: 114–119 DOI 10.1007/s11805-011-0568-6 Received April 21, 2011; accepted May 19, 2011
