All-trans Retinoic Acid Induced the Differentiation of Human Glioma Cells
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Qing-xi LIU 1* Nan WANG 1* Xing-hua LIAO 1 Guang-da REN 1 Tao QIN 1 Ru-fa YU 1 Cai-lian CHENG 2 Guang-cun LIU 3 Tong-cun ZHANG 1,2
- چاپ و سال / کشور: 2011
Description
Glioblastoma is a highly invasive and proliferative brain tumor in humans[ 1]. It is highly resistant to current therapies, causing signifi cant morbidity and mortality in patients, who rarely survive for 1 year after diagnosis[2]. Differentiation therapy has been shown effective in treatment of several types of cancer cells and may prove be effective in treatment of glioblastoma multiforme, the most common and most aggressive primary brain tumor[3,4]. All-trans retinoic acid (ATRA) is one of the strongest and most thoroughly studied differentiation inducers. It can induce the differentiation and apoptosis of a variety of tumor cells including glioma cells[5]. Because ATRA inhibits growth and induces differentiation, it in combination with another therapeutic agent[6]. It has been reported that combination of ATRA and paclitaxel induced differentiation and apoptosis in human glioblastoma U87MG xenografts[7]. However, the molecular mechanisms of glioma cell differentiation induced by ATRA have not been fully elucidated. In this paper, we reported that ATRA could induce the differentiation of human glioma cells. During the differentiation of human glioma cells, the mRNA levels of Retinoid X receptor ل (RXRل) and p21 were increased. Moreover, we constructed the luciferase reporter gene plasmid containing p21 promoter, and the luciferase assay confi rmed that ATRA and RXRل could transactivate p21 promoter in COS-7 and glioma cells.
Clin Oncol Cancer Res (2011) 8: 42-46 DOI 10.1007/s11805-011-0558-8 Received February 18, 2011; accepted March 20, 2011.
