T-helper-related cytokines in gingival crevicular fluid from adolescents with Down syndrome
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Georgios Tsilingaridis & Tülay Yucel-Lindberg & Thomas Modéer
- چاپ و سال / کشور: 2010
Description
Subjects with Down syndrome have a high prevalence of periodontal disease. The aim was to investigate the level of Th1-, Th2- and Th17-related cytokines in the gingival crevicular fluid (GCF) of subjects with Down syndrome. Subjects with Down syndrome (n=24) and controls (n=29) with a mean age of 16.4 years were clinically examined with respect to periodontal probing depth (PD) and gingival inflammation in terms of bleeding on probing (BOP%). The controls were matched to subjects with Down syndrome regarding age and gingival inflammation (BOP%). All subjects answered a questionnaire regarding oral hygiene, medical history and socioeconomic background. GCF was collected and the concentration of the cytokines, IFN-م, TNF-ل, IL-1â, IL-4, IL-6, IL-10, IL- 12 and IL-17 were determined using Bio-Plex cytokine multiplex assays. The volume of GCF (microliters) was significantly higher in subjects with Down syndrome (P< 0.001) compared with controls. The mean concentrations (picogrammes per millilitre) of IL-1â (P<0.001), IL-4 (P= 0.002), IL-6 (P=0.005), IL-10 (P=0.001), IL-12 (P=0.003), IFN-م (P=0.002), and TNF-ل (P=0.002) in GCF, respectively, were significantly higher in subjects with Down syndrome compared with controls. The regression line of the relationship between IFN-م and IL-4 in GCF differed significantly (P=0.006) in subjects with Down syndrome compared to controls. Subjects with Down syndrome demonstrated higher concentration of Th1-, Th2- and Th17-related cytokines with an altered relationship between Th1 cytokine, IFN-م and Th2 cytokine, IL-4, in volume GCF compared to controls
Clin Oral Invest DOI 10.1007/s00784-010-0495-6 Received: 9 November 2009 / Accepted: 6 December 2010
