Heart rate reduction in cardiovascular disease and therapy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jan-Christian Reil Florian Custodis Karl Swedberg Michel Komajda Jeffrey S. Borer Ian Ford Luigi Tavazzi Ulrich Laufs Michael Bo¨hm
- چاپ و سال / کشور: 2010
Description
Heart rate influences myocardial oxygen demand, coronary blood flow, and myocardial function. Clinical and experimental studies support an association between elevated resting heart rate and a broad range of maladaptive effects on the function and structure of the cardiovascular system. Heart rate has been shown to be an important predictor of mortality in cardiovascular disorders such as coronary artery disease, myocardial infarction, and chronic heart failure. This review summarizes the specific influence of heart rate on vascular morphology and function as well as on myocardial lesions leading from early impact on vascular homeostasis to myocardial hemodynamics in chronic heart failure. Heart rate can be easily determined during physical examination of the patient and therefore allows a simple hint on prognosis and efficiency of therapy.
Clin Res Cardiol (2011) 100:11–19 DOI 10.1007/s00392-010-0207-x Received: 7 May 2010 / Accepted: 3 August 2010 / Published online: 1 September 2010
