Effects of intracoronary injection of autologous bone marrowderived stem cells on natriuretic peptides and inflammatory markers in patients with acute ST-elevation myocardial infarction
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Johanna A. Miettinen Kari Ylitalo Pirjo Hedberg Kari Kervinen Matti Niemela¨ Marjaana Sa¨ily Pirjo Koistinen Eeva-Riitta Savolainen Heik
- چاپ و سال / کشور: 2010
Description
Background Intracoronary administration of autologous bone marrow stem cells (BMC) has been shown to result in a subtle improvement of global left ventricular ejection fraction after ST-elevation myocardial infarction (STEMI), but the overall benefits of BMC therapy are still unclear. We studied the influence of intracoronary injections of BMC on levels of natriuretic peptides and inflammatory mediators, which are well established prognostic biomarkers, in patients with STEMI. Methods In this randomized, double-blind study, consecutive patients with an acute STEMI treated with thrombolysis followed by PCI 2–6 days after STEMI, were randomly assigned to receive either intracoronary BMC or placebo medium into the infarct-related artery. Blood samples were drawn for biochemical determinations. Results From baseline to 6 months, there was a significant decrease in the levels of N-terminal probrain natriuretic peptide (NT-proBNP), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) in the whole patient population (P\0.001 for all). However, no difference was observed between the BMC group (n = 39) and the placebo group (n = 39) in the change of the levels of NT-proANP (median -54 vs. ?112 pmol/L), NT-proBNP (-88 vs. -115 pmol/L) or inflammatory markers IL-6 (-3.86 vs. -5.61 pg/mL), hsCRP (-20.29 vs. -22.36 mg/L) and tumor necrosis factor a (-0.12 vs. -0.80 pg/mL) between baseline and 6 months. Conclusion Intracoronary BMC therapy does not appear to exert any significant effects on the secretion of natriuretic peptides or inflammatory biomarkers in STEMI patients
Clin Res Cardiol (2011) 100:317–325 DOI 10.1007/s00392-010-0246-3 Received: 26 April 2010 / Accepted: 1 October 2010 / Published online: 17 October 2010
