Estrogen Receptors in Immunity and Autoimmunity
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Melissa Cunningham & Gary Gilkeson
- چاپ و سال / کشور: 2011
Description
Due to the female predominance of autoimmune diseases, the role of gender and sex hormones in the immune system is of long-term interest. Estrogen's primary effects are mediated via estrogen receptors alpha and beta (ER ل/â) that are expressed on most immune cells. ERs are nuclear hormone receptors that can either directly bind to estrogen response elements in gene promoters or serve as cofactors with other transcription factors (i.e., NFkB/AP1). Cytoplasmic ER and membrane associated ER impact specific kinase signaling pathways. ERs have prominent effects on immune function in both the innate and adaptive immune responses. Genetic deficiency of ERل in murine models of lupus resulted in significantly decreased disease and prolonged survival, while ERâ deficiency had minimal to no effect in autoimmune models. The protective effect of ERل in lupus is multifactoral. In arthritis models, ERل agonists appears to mediate a protective effect. The modulation of ERل function appears to be a potential target for therapy in autoimmunity
Clinic Rev Allerg Immunol (2011) 40:66–73 Published online: 30 March 2010
