Cathepsin L in Normal and Pathological Bone Remodeling
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : G. Leto M. Crescimanno C. Flandina M. V. Sepporta F. M. Tumminello
- چاپ و سال / کشور: 2011
Description
Cathepsin L is a ubiquitous lysosomal cysteine endopeptidase that is mainly involved in the metabolic turnover of intracellular proteins. However, it is now well established that this enzyme may also be implicated in the regulation of other important biological processes including bone resorption. Therefore, altered expression levels of Cathepsin L may result in disturbances of bone homeostasis and, eventually, in the onset of pathological conditions associated with altered bone turnover. These observations support the concept that Cathepsin L may be regarded as an additional target for the development of novel therapeutic options for the treatment of patients with bone diseases. This review provides insight into the most recent advances in understanding the role of Cathepsin L in normal and pathological bone remodeling and discusses the potential clinical and therapeutic applications related to these findings.
Clinic Rev Bone Miner Metab (2011) 9:107–121 Published online: 23 June 2011
