Comparison of performance of the Assessment of Spondyloarthritis International Society, the European Spondyloarthropathy Study Group and the modified New York criteria in a cohort of Chinese patients with spondyloarthritis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ho Yin Chung & Chak Sing Lau & Ka Pik Wu & Woon Sing Wong & Mo Yin MOK
- چاپ و سال / کشور: 2011
Description
Early diagnosis of spondyloarthritis (SpA) is essential as anti-tumor necrosis factor therapy can achieve significant symptomatic relief and control of disease activity. This study aims to compare the clinical characteristics, disease activity, and functional status of a Chinese cohort of SpA patients who were re-classified into ankylosing spondylitis (AS) patients fulfilling the modified New York (MNY) criteria, those with undifferentiated SpA (USpA) fulfilling the European Spondyloarthropathy Study Group (ESSG) classification criteria only (USpA/ESSG) and those who fulfill Assessment of SpondyloArthritis International Society (ASAS) only (USpA/ASAS). Disease activity was evaluated by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), severity of morning stiffness, patient global assessment, and C-reactive protein. Functional status was evaluated by Bath Ankylosing Spondylitis Functional Index (BASFI), modified Schober index, and dimension of chest expansion. One hundred and twenty-eight patients with disease duration of 16.3±10.4 years were recruited. Patients in USpA/ESSG and USpA/ASAS were significantly younger (p=0.01), had shorter disease duration (p<0.01), and lower BASFI (p=0.03) than established AS patients. All three groups have active disease with comparable BASDAI >3. BASFI correlated inversely with dimension of chest expansion and negatively modified Schober index in AS patients (p<0.01) and modestly with BASDAI (r=0.25, p<0.01). BASFI correlated moderately with BASDAI in USpA/ESSG (r=0.61, p<0.01) but not with chest expansion or modified Schober index. Compared with established AS patients recognized by MNY criteria, patients fulfilling USpA defined by ESSG or ASAS criteria had earlier disease, as active disease and less irreversible functional deficit.
Clin Rheumatol (2011) 30:947–953 Received: 22 June 2010 / Revised: 7 December 2010 / Accepted: 13 January 2011 / Published online: 19 February 2011
