Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Koichi Yanaba & Ayumi Yoshizaki & Yoshihide Asano & Takafumi Kadono & Shinichi Sato
- چاپ و سال / کشور: 2011
Description
To determine serum interleukin-33 (IL-33) levels and their associations with clinical parameters in patients with systemic sclerosis (SSc). Serum IL-33 levels were examined by enzyme-linked immunosorbent assay in 69 patients with SSc and 30 healthy individuals. In a retrospective longitudinal study, sera from 14 patients with SSc were analyzed (follow-up, 1–7 years). Serum IL-33 levels were elevated in SSc patients (261.7±141.9 pg/ml) compared with healthy individuals (174.9±72.4 pg/ml; P< 0.001). Patients with diffuse cutaneous SSc had higher levels of IL-33 (287.5±146.6 pg/ml) than those with limited cutaneous SSc (221.5±126.5 pg/ml; P<0.05). Pulmonary fibrosis and decreased forced vital capacity were more commonly found in patients with elevated IL-33 levels than in those with normal IL-33 levels. IL-33 levels correlated positively with the extent of skin sclerosis, and inversely with percent predicted forced vital capacity. IL-33 levels were increased in SSc patients and correlated with the extent of skin sclerosis and the severity of pulmonary fibrosis. Therefore, IL-33 possibly plays a role in cutaneous and pulmonary fibrosis in SSc patients.
Clin Rheumatol (2011) 30:825–830 Received: 25 May 2010 / Revised: 29 December 2010 / Accepted: 6 January 2011 / Published online: 19 January 2011
