Synovial fluid â-endorphin level in avascular necrosis, rheumatoid arthritis, and osteoarthritis of the femoral head and knee. A controlled pilot study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kلlmلn Toth & Istvلn Barna & Gyِrgy Nagy & Karoly Wellinger & Gyِngyi Horvath & Tamas Bender
- چاپ و سال / کشور: 2011
Description
The goal of this study is to determine and compare the â-endorphin levels in the synovial fluid of patients with different joint disorders (avascular necrosis, AVN; osteoarthritis, OA; and rheumatoid arthritis, RA of the hip or knee). Eighty-seven patients were involved in our study with an average age of 62 years. Thirty-three patients had AVN (18 hips, 15 knees). Twenty-three patients were diagnosed with OA (14 hips, 9 knees), and 31 patients suffered from RA (12 hips, 19 knees). We measured the â- endorphin levels of the synovial fluids -harvested from surgery—with radioimmunoassay. No significant difference was found in the â-endorphin levels of the synovial fluid from AVN comparing to OA and RA, however â- endorphin level was significantly higher in RA group than among patients with OA (p=0.01). Synovial â-endorphin level was slightly lower in knee comparing to hip joint p= (0.06). When examining the different joints separately in compliance with diagnoses, we concluded that the synovial â-endorphin level from AVN was between the values of OA and RA without significant difference, whereas it was significantly higher in the knee of RA, than of OA groups (p=0.05 knee, p=0.2 hip). Our results confirmed those experiments which stated that there is a significant increase in synovial â-endorphin level in patients with inflammatory autoimmune diseases (e.g., RA), comparing to the level measured in degenerative conditions (e.g., OA).
Clin Rheumatol (2011) 30:537–540 Received: 9 February 2010 / Revised: 4 August 2010 / Accepted: 7 September 2010 / Published online: 21 September 2010
