Takayasu’s arteritis progression on anti-TNF biologics: a case series
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mohammed Osman & Stephen Aaron & Michelle Noga & Elaine Yacyshyn
- چاپ و سال / کشور: 2011
Description
Takayasu’s arteritis (TA) is a rare granulomatous vasculitic disease that affects the aorta and its major branches. Recent studies have suggested that anti-TNFل biological therapies are highly effective in treating TA refractory to conventional immunosuppressive therapy. We describe two patients with TA: one with progressive TA despite management with two different anti-TNFل agents, infliximab and adalimumab, and another who developed TA while treated with infliximab for the management of pre-existing Crohn’s disease. From our observations, we believe that a multicentered randomized study should be designed to assess the extent of resistance to these agents when different therapeutic doses are employed for managing TA.
Clin Rheumatol (2011) 30:703–706 Received: 10 March 2010 / Revised: 7 December 2010 / Accepted: 8 December 2010 / Published online: 11 January 2011
